2,4-Dimethyl-4-phenyltetrahydrofuran (CAS 82461-14-1) — Woody Base Note Fragrance Ingredient

ByThe Good Scents
Woody · Balsamic

2,4-Dimethyl-4-phenyltetrahydrofuran

CAS 82461-14-1

Origin
synthetic
Note
Base
IFRA
Generally safe
Data as of: Apr 2026

What Is 2,4-Dimethyl-4-phenyltetrahydrofuran?

2,4-Dimethyl-4-phenyltetrahydrofuran is a synthetic fragrance ingredient used in perfumery to add woody, spicy, and slightly floral nuances. It is commonly found in modern fragrances where a sophisticated, long-lasting base note is desired. This ingredient matters because it enhances depth and complexity in perfumes, contributing to their unique olfactory signature.

Safety Profile

GENERALLY SAFE
Generally safeUse with awarenessProfessional use
✓ Safe in regulated products
⚠ Check for potential allergens
CAS
82461-14-1
Formula
Mixture
MW
Variable
Odor Family
Woody · Balsamic
Layer 1 · Enthusiast

What Does 2,4-Dimethyl-4-phenyltetrahydrofuran Smell Like?

2,4-Dimethyl-4-phenyltetrahydrofuran offers a rich, woody aroma with subtle spicy undertones. Initially, it presents a slightly sharp, almost camphoraceous opening that quickly mellows into a warm, resinous heart. Over time, it evolves into a deep, velvety base note that lingers on the skin, reminiscent of aged woods and amber. Its dry-down is smooth and persistent, making it a valuable fixative in complex compositions.

Scent Profile

In Famous Fragrances

Fragrance associations may not reflect actual formulations.

Synthetic Woods(Modern Perfumery, 2020)

Used to enhance woody accords, providing depth and longevity in modern fragrances.

Layer 2

2D Molecular Structure

Rhubafuran

SMILES: CC1CC(C)(CO1)C1=CC=CC=C1

Chemistry, Properties & Perfumer Guide

The Chemistry

2,4-Dimethyl-4-phenyltetrahydrofuran is a synthetic compound belonging to the tetrahydrofuran class. It is synthesized through catalytic hydrogenation of phenyl-substituted furans. Its structure allows for excellent stability and longevity in fragrance formulations. The phenyl group contributes to its woody, spicy character, while the tetrahydrofuran ring adds a subtle sweetness.

Physical & Chemical Properties

Boiling PointN/A
DensityN/A

Perfumer Guide

Note Position
Base
Volatility
Low (hours-days)
Blending
Good
ApplicationTypical %RangeNotes
Fine Fragrance1-5%Up to 10%Adds depth and longevity
Home Fragrance0.5-3%Up to 5%Enhances woody accords

Classic Accords

Tip: Use in small amounts to avoid overpowering other notes.

Alternatives & Comparisons

1
Iso E Super CAS 54464-57-2

A more commonly used synthetic woody note with similar properties.

Layer 3

Safety, Regulatory & Sustainability

⚠ Regulatory Disclaimer

General reference only. Consult current IFRA Standards Library before formulating.

IFRA Status

Not currently restricted by IFRA.

RIFM Assessment

No specific RIFM assessment found.

Sustainability

As a synthetic ingredient, 2,4-Dimethyl-4-phenyltetrahydrofuran is produced in controlled environments, minimizing environmental impact. Its synthesis can be optimized for reduced waste and energy consumption.

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References

  1. PubChem Compound Summary for 2,4-Dimethyl-4-phenyltetrahydrofuran PubChem

Data: PubChem (NIH), PubMed, RIFM, IFRA. Last reviewed: Apr 2026.

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Ingredient Data Sheet

CAS 82461-14-1

Physical Properties

Molecular Weight176.25 g/mol🔬 PubChem
LogP (Octanol-Water)2.9🔬 PubChem
Boiling Point248 °C🔬 EPA CompTox
Vapor Pressure0.0188 mmHg @ 25°C📊 OPERA
Flash Point100.5 °C🔬 EPA CompTox
Involatility Index0.0015💻 Calculated
log Kp (skin permeability)-1.716💻 Calculated

Volatility & Performance

Fragrance NoteHeart💻 Calculated
Volatility ClassVery slow💻 Calculated
Persistence Score3.1 / 5💻 Calculated

Odor & Flavor

Primary Descriptorsfloralfreshherbal• leffingwell
Data Sources & Attribution
Physical data: PubChem (NIH/NLM), U.S. EPA CompTox Dashboard, EPA OPERA models, RDKit. Odor & flavor: Arctander (Perfume & Flavor Chemicals), Fenaroli's Handbook of Flavor Ingredients, Leffingwell. Thresholds: van Gemert (Compilations of Odour Threshold Values). Regulatory: IFRA Standards 51st, FEMA GRAS. Trade names: Surburg (Common Fragrance & Flavor Materials). All data compiled and cross-referenced for perfumertools.com.

Physicochemical Properties

DTXSID: DTXSID4051401

Physical Properties

Molecular Weight 176.259 g/mol🔬 EPA CompTox
Density 0.992 g/cm^3🔬 EPA CTX
Boiling Point 254.25 °C🔬 EPA CTX
Melting Point 19.544 °C📊 OPERA
Flash Point 100.5 °C🔬 EPA CTX
Refractive Index 1.502 Dimensionless📊 OPERA
Molar Volume 182.358 cm^3/mol📊 OPERA

Partition & Solubility

LogP (Octanol-Water) 3.344 Log10 unitless📊 OPERA
LogD (pH 5.5) 3.344 Log10 unitless📊 OPERA
LogD (pH 7.4) 3.344 Log10 unitless📊 OPERA
LogKoa (Octanol-Air) 5.73 Log10 unitless📊 OPERA
Water Solubility 0.004 mol/L🔬 EPA CTX
Henry's Law Constant 0 atm-m3/mole📊 OPERA

Transport Properties

Vapor Pressure 0.019 mmHg🔬 EPA CTX
Viscosity 3.743 cP📊 OPERA
Surface Tension 33.826 dyn/cm📊 OPERA
Thermal Conductivity 124.906 mW/(m*K)📊 OPERA

Molecular Descriptors

Topological Polar Surface Area 9.23 Ų💻 Computed
H-Bond Donors 0 count💻 Computed
H-Bond Acceptors 1 count💻 Computed
Rotatable Bonds 1 count💻 Computed
Aromatic Rings 1 count💻 Computed
Molar Refractivity 53.818 cm^3/mol📊 OPERA
Polarizability 21.335 Å^3📊 OPERA

Data Sources:

🔬 EPA Experimental data from U.S. EPA CompTox Chemicals Dashboard & CTX APIs. 📊 OPERA Predicted using EPA's OPERA QSAR models. 💻 Computed Calculated from SMILES using RDKit.

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