4,6-Dimethylcyclohex-3-ene-1-carbaldehyde (CAS 36635-35-5) — Green Top to Mid Note Fragrance Ingredient
4,6-Dimethylcyclohex-3-ene-1-carbaldehyde
CAS 36635-35-5
What Is 4,6-Dimethylcyclohex-3-ene-1-carbaldehyde?
4,6-Dimethylcyclohex-3-ene-1-carbaldehyde is a synthetic fragrance ingredient used in modern perfumery to add woody, green nuances. You’ll encounter it in contemporary fragrances where it contributes to fresh, natural-smelling accords. This aldehyde is valued for its ability to bridge herbal and woody notes, creating complexity without overwhelming other ingredients. It’s particularly useful in unisex and masculine fragrances where crisp, outdoorsy elements are desired.
Safety Profile
GENERALLY SAFEWhat Does 4,6-Dimethylcyclohex-3-ene-1-carbaldehyde Smell Like?
This synthetic aldehyde opens with a crisp, green character reminiscent of crushed leaves and fresh-cut stems, with subtle citrus undertones. As it evolves, a woody heart emerges – like sun-warmed cedar with a touch of camphoraceous coolness. The dry-down reveals a clean, slightly earthy base that blends seamlessly with musks and amber materials. Its medium volatility allows it to serve as both a top and heart note contributor, making it versatile in modern fragrance architectures.
In Famous Fragrances
Fragrance associations may not reflect actual formulations.
Used to enhance the mineral, earthy qualities of the fragrance, contributing to its distinctive flinty character that complements the grapefruit and vetiver.
Adds a subtle green woody facet to the citrus-amber accord, helping bridge the fresh top notes with the deeper base elements.
2D Molecular Structure
SMILES: CC1CC(C)=CCC1C=O
Chemistry, Properties & Perfumer Guide
The Chemistry
4,6-Dimethylcyclohex-3-ene-1-carbaldehyde belongs to the class of cyclohexenyl aldehydes, characterized by their unsaturated six-membered ring structure with an aldehyde functional group. The dimethyl substitution at positions 4 and 6 creates steric hindrance that influences both the molecule’s odor characteristics and its chemical reactivity. While not found in nature, it’s synthesized through Diels-Alder reactions or selective oxidation of corresponding alcohols. The molecule’s conformational flexibility allows it to interact with multiple olfactory receptors, contributing to its complex scent profile.
Physical & Chemical Properties
| Appearance | Colorless to pale yellow liquid |
|---|---|
| Boiling Point | Estimated 200-220°C |
| Density | Approx. 0.95 g/cm³ |
Perfumer Guide
| Application | Typical % | Range | Notes |
|---|---|---|---|
| Fine Fragrance | 0.5-2% | Up to 5% | Background modifier |
| Functional Fragrances | 0.1-0.5% | Up to 1% | Freshness booster |
Classic Accords
Tip: Use in trace amounts to add lift to woody compositions without dominating the blend.
Alternatives & Comparisons
For a more floral, lily-of-the-valley character while maintaining similar green freshness.
Offers comparable green aspects with more pronounced citrus and herbal nuances.
Safety, Regulatory & Sustainability
⚠ Regulatory Disclaimer
General reference only. Consult current IFRA Standards Library before formulating.
IFRA Status
Not currently restricted under IFRA standards. No specific limitations apply.
RIFM Assessment
No formal RIFM assessment available. Considered low risk based on structural analogs.
Sustainability
As a synthetic material, this aldehyde doesn’t rely on natural resources for production. Its synthesis can be optimized for atom economy and reduced waste streams. Being produced in controlled industrial settings allows for consistent quality and reduced environmental impact compared to some natural ingredient extraction processes.
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References
- Burdock, G.A. (2010). Fenaroli’s Handbook of Flavor Ingredients. CRC Press. ISBN 9781439847503
Data: PubChem (NIH), PubMed, RIFM, IFRA. Last reviewed: Apr 2026.
Report a data errorIngredient Data Sheet
CAS 36635-35-5Physical Properties
| Molecular Weight | 138.21 g/mol🔬 PubChem |
| LogP (Octanol-Water) | 1.6🔬 PubChem |
| Boiling Point | 203 °C🔬 EPA CompTox |
| Vapor Pressure | 0.2818 mmHg @ 25°C📊 OPERA |
| Flash Point | 69.2 °C🔬 EPA CompTox |
| Involatility Index | 0.0258💻 Calculated |
| log Kp (skin permeability) | -2.407💻 Calculated |
| SMILES | CC1CC(=CCC1C=O)C🔬 PubChem |
Volatility & Performance
| Fragrance Note | Heart💻 Calculated |
| Volatility Class | Slow💻 Calculated |
| Persistence Score | 0.8 / 5💻 Calculated |
Odor & Flavor
| Primary Descriptors | greenwoody• leffingwell |
| Functional Groups | aldehydealkene💻 RDKit |
Regulatory Status
| IFRA Listed | Yes — see IFRA Standards for category limits⚖️ IFRA 51 |
Physical data: PubChem (NIH/NLM), U.S. EPA CompTox Dashboard, EPA OPERA models, RDKit. Odor & flavor: Arctander (Perfume & Flavor Chemicals), Fenaroli's Handbook of Flavor Ingredients, Leffingwell. Thresholds: van Gemert (Compilations of Odour Threshold Values). Regulatory: IFRA Standards 51st, FEMA GRAS. Trade names: Surburg (Common Fragrance & Flavor Materials). All data compiled and cross-referenced for perfumertools.com.
Physicochemical Properties
DTXSID: DTXSID60893056
Physical Properties
| Molecular Weight | 138.21 g/mol🔬 EPA CompTox |
| Density | 0.935 g/cm^3📊 OPERA |
| Boiling Point | 194.168 °C📊 OPERA |
| Melting Point | 1.278 °C📊 OPERA |
| Flash Point | 65.082 °C📊 OPERA |
| Refractive Index | 1.512 Dimensionless📊 OPERA |
| Molar Volume | 144.3 cm^3/mol📊 OPERA |
Partition & Solubility
| LogP (Octanol-Water) | 2.711 Log10 unitless📊 OPERA |
| LogD (pH 5.5) | 2.711 Log10 unitless📊 OPERA |
| LogD (pH 7.4) | 2.711 Log10 unitless📊 OPERA |
| LogKoa (Octanol-Air) | 4.32 Log10 unitless📊 OPERA |
| Water Solubility | 0.01 mol/L📊 OPERA |
| Henry's Law Constant | 0 atm-m3/mole📊 OPERA |
Transport Properties
| Vapor Pressure | 0.389 mmHg📊 OPERA |
| Viscosity | 2.055 cP📊 OPERA |
| Surface Tension | 34.448 dyn/cm📊 OPERA |
| Thermal Conductivity | 125.966 mW/(m*K)📊 OPERA |
Molecular Descriptors
| Topological Polar Surface Area | 17.07 Ų💻 Computed |
| H-Bond Donors | 0 count💻 Computed |
| H-Bond Acceptors | 1 count💻 Computed |
| Rotatable Bonds | 1 count💻 Computed |
| Aromatic Rings | 0 count💻 Computed |
| Molar Refractivity | 43.295 cm^3/mol📊 OPERA |
| Polarizability | 17.164 Å^3📊 OPERA |
Data Sources:
🔬 EPA Experimental data from U.S. EPA CompTox Chemicals Dashboard & CTX APIs. 📊 OPERA Predicted using EPA's OPERA QSAR models. 💻 Computed Calculated from SMILES using RDKit.
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