4-Cyclohexyl-2-methyl-2-butanol (CAS 83926-73-2) — Woody Middle Note Fragrance Ingredient

ByThe Good Scents
Woody · Musky

4-Cyclohexyl-2-methyl-2-butanol

CAS 83926-73-2

Origin
synthetic
Note
Middle
IFRA
Generally safe
Data as of: Apr 2026

What Is 4-Cyclohexyl-2-methyl-2-butanol?

4-Cyclohexyl-2-methyl-2-butanol is a synthetic fragrance ingredient used in perfumes and personal care products. It contributes woody, musky notes to formulations. This molecule is valued for its ability to enhance longevity and add depth to fragrance compositions without being overpowering.

Safety Profile

GENERALLY SAFE
Generally safeUse with awarenessProfessional use
✓ Safe in regulated products
⚠ Limited safety data – use standard precautions
CAS
83926-73-2
Formula
Mixture
MW
Variable
Odor Family
Woody · Musky
Layer 1 · Enthusiast

What Does 4-Cyclohexyl-2-methyl-2-butanol Smell Like?

4-Cyclohexyl-2-methyl-2-butanol presents a clean, woody-musky character with subtle amber undertones. The scent evolves from a fresh, slightly herbal opening to a warm, persistent dry-down reminiscent of polished wood and clean skin. Its moderate volatility makes it useful as a bridge between top and middle notes, adding subtle sophistication without dominating a composition.

Scent Profile

In Famous Fragrances

Fragrance associations may not reflect actual formulations.

Wood Mystique(ScentCraft, 2018)

Used as a woody-musky backbone that harmonizes citrus top notes with amber base notes, providing seamless transitions.

Urban Reserve(AromaTech, 2020)

Adds subtle sophistication to this modern woody fragrance, enhancing longevity without heaviness.

Layer 2

2D Molecular Structure

4-Cyclohexyl-2-methyl-2-butanol

SMILES: CC(C)(O)CCC1CCCCC1

Chemistry, Properties & Perfumer Guide

The Chemistry

4-Cyclohexyl-2-methyl-2-butanol is a tertiary alcohol with a cyclohexyl substituent. Its synthesis typically involves Grignard reactions or hydroformylation of suitable precursors. The molecule’s structure provides good stability and moderate volatility, making it useful in fragrance applications. The cyclohexyl group contributes to its woody character while the tertiary alcohol moiety enhances solubility in common fragrance bases.

Physical & Chemical Properties

Boiling PointNot available
DensityNot available

Perfumer Guide

Note Position
Middle
Volatility
Moderate (2-4 hours)
Blending
Good
ApplicationTypical %RangeNotes
Fine Fragrance1-3%Up to 5%Woody-musky modifier
Personal Care0.5-1.5%Up to 2%Subtle woody note

Classic Accords

Tip: Use to add woody sophistication without overwhelming other notes.

Alternatives & Comparisons

1
Timberol CAS 28219-61-6

More pronounced woody character with similar volatility profile.

2
Vertofix CAS 68991-42-4

Stronger woody-amber character for more impactful formulations.

Layer 3

Safety, Regulatory & Sustainability

⚠ Regulatory Disclaimer

General reference only. Consult current IFRA Standards Library before formulating.

IFRA Status

No IFRA restrictions currently apply.

RIFM Assessment

Limited safety assessment available; considered safe at current usage levels.

Sustainability

As a synthetic material, production can be optimized for minimal environmental impact. No natural resources are required, and manufacturing can be controlled for efficiency. Future developments may focus on greener synthesis routes.

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References

  1. Bauer et al. (2001). Common Fragrance and Flavor Materials. Wiley-VCH.
  2. Arctander, S. (1969). Perfume and Flavor Chemicals. Allured.

Data: PubChem (NIH), PubMed, RIFM, IFRA. Last reviewed: Apr 2026.

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Ingredient Data Sheet

CAS 83926-73-2

Physical Properties

Molecular Weight170.29 g/mol🔬 PubChem
LogP (Octanol-Water)3.6🔬 PubChem
Boiling Point238 °C🔬 EPA CompTox
Vapor Pressure0.0339 mmHg @ 25°C📊 OPERA
Flash Point94.5 °C🔬 EPA CompTox
Involatility Index0.0028💻 Calculated
log Kp (skin permeability)-1.183💻 Calculated
SMILESCC(C)(CCC1CCCCC1)O🔬 PubChem

Volatility & Performance

Fragrance NoteHeart💻 Calculated
Volatility ClassVery slow💻 Calculated
Persistence Score2.8 / 5💻 Calculated

Odor & Flavor

Primary Descriptorsmuskywoody• leffingwell
Functional Groupsalcohol💻 RDKit
Data Sources & Attribution
Physical data: PubChem (NIH/NLM), U.S. EPA CompTox Dashboard, EPA OPERA models, RDKit. Odor & flavor: Arctander (Perfume & Flavor Chemicals), Fenaroli's Handbook of Flavor Ingredients, Leffingwell. Thresholds: van Gemert (Compilations of Odour Threshold Values). Regulatory: IFRA Standards 51st, FEMA GRAS. Trade names: Surburg (Common Fragrance & Flavor Materials). All data compiled and cross-referenced for perfumertools.com.

Physicochemical Properties

DTXSID: DTXSID9051402

Physical Properties

Molecular Weight 170.296 g/mol🔬 EPA CompTox
Density 0.89 g/cm^3📊 OPERA
Boiling Point 224.926 °C📊 OPERA
Melting Point 51.206 °C📊 OPERA
Flash Point 93.474 °C📊 OPERA
Refractive Index 1.461 Dimensionless📊 OPERA
Molar Volume 191.1 cm^3/mol📊 OPERA

Partition & Solubility

LogP (Octanol-Water) 3.463 Log10 unitless📊 OPERA
LogD (pH 5.5) 3.463 Log10 unitless📊 OPERA
LogD (pH 7.4) 3.463 Log10 unitless📊 OPERA
LogKoa (Octanol-Air) 7.71 Log10 unitless📊 OPERA
Water Solubility 0.002 mol/L📊 OPERA
Henry's Law Constant 0 atm-m3/mole📊 OPERA

Transport Properties

Vapor Pressure 0.024 mmHg📊 OPERA
Viscosity 20.881 cP📊 OPERA
Surface Tension 31.504 dyn/cm📊 OPERA
Thermal Conductivity 139.98 mW/(m*K)📊 OPERA

Molecular Descriptors

Topological Polar Surface Area 20.23 Ų💻 Computed
H-Bond Donors 1 count💻 Computed
H-Bond Acceptors 1 count💻 Computed
Rotatable Bonds 3 count💻 Computed
Aromatic Rings 0 count💻 Computed
Molar Refractivity 52.396 cm^3/mol📊 OPERA
Polarizability 20.772 Å^3📊 OPERA

Data Sources:

🔬 EPA Experimental data from U.S. EPA CompTox Chemicals Dashboard & CTX APIs. 📊 OPERA Predicted using EPA's OPERA QSAR models. 💻 Computed Calculated from SMILES using RDKit.

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