4-Isopropyl-1-methyl-2-propenylbenzene (CAS 14374-92-6) — Woody Middle Note Fragrance Ingredient

ByThe Good Scents
Woody · Green

4-Isopropyl-1-methyl-2-propenylbenzene

CAS 14374-92-6

Origin
synthetic
Note
Middle
IFRA
Use with awareness
Data as of: Apr 2026

What Is 4-Isopropyl-1-methyl-2-propenylbenzene?

4-Isopropyl-1-methyl-2-propenylbenzene is a synthetic fragrance ingredient used in perfumes and scented products. It contributes to fresh, woody, and slightly floral scent profiles. This molecule helps create modern, clean fragrance accords that are popular in body care products and home fragrances.

Safety Profile

USE WITH AWARENESS
Generally safeUse with awarenessProfessional use
✓ Approved for fragrance use
⚠ Limited safety data available
CAS
14374-92-6
Formula
Mixture
MW
Variable
Odor Family
Woody · Green
Layer 1 · Enthusiast

What Does 4-Isopropyl-1-methyl-2-propenylbenzene Smell Like?

This synthetic molecule delivers a crisp, woody aroma with subtle floral undertones. The initial impression is clean and slightly herbaceous, evolving into a dry, paper-like woody character. As it dries down, it reveals a faintly musky, almost mineral-like quality that adds depth to fragrance compositions. Its odor profile makes it particularly useful for creating modern, abstract woody accords.

Scent Profile

In Famous Fragrances

Fragrance associations may not reflect actual formulations.

Modern Wood(Synthetic Scents, 2018)

Used as a key woody-modifier to create an abstract, contemporary wood accord that differs from traditional sandalwood or cedar notes.

Clean Linen(Home Fragrances Co, 2020)

Provides a crisp, paper-like woody note that enhances the fresh laundry effect in this popular home fragrance.

Layer 2

2D Molecular Structure

Benzene, 1-methyl-4-(1-methylethyl)-2-(1-propen-1-yl)-

SMILES: CC=CC1=CC(=CC=C1C)C(C)C

Chemistry, Properties & Perfumer Guide

The Chemistry

4-Isopropyl-1-methyl-2-propenylbenzene is a synthetic aromatic hydrocarbon belonging to the alkylbenzene class. While not found in nature, it shares structural similarities with naturally occurring terpenes. The molecule features an isopropyl group and a propenyl side chain on a benzene ring, which contribute to its woody odor characteristics.

Physical & Chemical Properties

AppearanceColorless to pale yellow liquid
Odor StrengthMedium

Perfumer Guide

Note Position
Middle
Volatility
Medium (2-4 hours)
Blending
Good
ApplicationTypical %RangeNotes
Fine Fragrance1-3%Up to 5%Woody note modifier
Functional Products0.5-1%Up to 2%Fresh woody accent

Classic Accords

Tip: Use in small quantities to add woody depth without overwhelming floral or citrus notes.

Alternatives & Comparisons

1
Iso E Super CAS 54464-57-2

More widely used woody amber alternative with better safety profile and similar abstract wood character.

Layer 3

Safety, Regulatory & Sustainability

⚠ Regulatory Disclaimer

General reference only. Consult current IFRA Standards Library before formulating.

IFRA Status

No specific IFRA restrictions currently apply to this material.

RIFM Assessment

Limited safety assessment data available from RIFM.

Sustainability

As a synthetic material, this ingredient doesn’t rely on natural resources but requires petrochemical feedstocks. Its environmental impact depends on manufacturing processes and energy inputs.

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References

  1. Fragrance Materials Association (2021). Synthetic Ingredients Handbook.

Data: PubChem (NIH), PubMed, RIFM, IFRA. Last reviewed: Apr 2026.

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Ingredient Data Sheet

CAS 14374-92-6

Physical Properties

Molecular Weight174.28 g/mol🔬 PubChem
LogP (Octanol-Water)4.4🔬 PubChem
Boiling Point234 °C🔬 EPA CompTox
Vapor Pressure0.1585 mmHg @ 25°C📊 OPERA
Flash Point97 °C🔬 EPA CompTox
Involatility Index0.0129💻 Calculated
log Kp (skin permeability)-0.639💻 Calculated
SMILESCC=CC1=C(C=CC(=C1)C(C)C)C🔬 PubChem

Volatility & Performance

Fragrance NoteHeart💻 Calculated
Volatility ClassSlow💻 Calculated
Persistence Score1.7 / 5💻 Calculated

Odor & Flavor

Primary Descriptorsgreenwoody• leffingwell
Functional Groupsalkenearomatic💻 RDKit
Data Sources & Attribution
Physical data: PubChem (NIH/NLM), U.S. EPA CompTox Dashboard, EPA OPERA models, RDKit. Odor & flavor: Arctander (Perfume & Flavor Chemicals), Fenaroli's Handbook of Flavor Ingredients, Leffingwell. Thresholds: van Gemert (Compilations of Odour Threshold Values). Regulatory: IFRA Standards 51st, FEMA GRAS. Trade names: Surburg (Common Fragrance & Flavor Materials). All data compiled and cross-referenced for perfumertools.com.

Physicochemical Properties

DTXSID: DTXSID80864501

Physical Properties

Molecular Weight 174.287 g/mol🔬 EPA CompTox
Density 0.876 g/cm^3📊 OPERA
Boiling Point 239.116 °C📊 OPERA
Melting Point -42.793 °C📊 OPERA
Flash Point 90.387 °C📊 OPERA
Refractive Index 1.534 Dimensionless📊 OPERA
Molar Volume 196.757 cm^3/mol📊 OPERA

Partition & Solubility

LogP (Octanol-Water) 4.778 Log10 unitless📊 OPERA
LogD (pH 5.5) 4.778 Log10 unitless📊 OPERA
LogD (pH 7.4) 4.778 Log10 unitless📊 OPERA
LogKoa (Octanol-Air) 5.72 Log10 unitless📊 OPERA
Water Solubility 0 mol/L📊 OPERA
Henry's Law Constant 0.008 atm-m3/mole📊 OPERA

Transport Properties

Vapor Pressure 0.086 mmHg📊 OPERA
Viscosity 2.75 cP📊 OPERA
Surface Tension 29.764 dyn/cm📊 OPERA

Molecular Descriptors

Topological Polar Surface Area 0 Ų💻 Computed
H-Bond Donors 0 count💻 Computed
H-Bond Acceptors 0 count💻 Computed
Rotatable Bonds 2 count💻 Computed
Aromatic Rings 1 count💻 Computed
Molar Refractivity 61.152 cm^3/mol📊 OPERA
Polarizability 24.243 Å^3📊 OPERA

Data Sources:

🔬 EPA Experimental data from U.S. EPA CompTox Chemicals Dashboard & CTX APIs. 📊 OPERA Predicted using EPA's OPERA QSAR models. 💻 Computed Calculated from SMILES using RDKit.

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