7-Cyclohexadecen-1-one, (7E) (CAS 854373-70-9) — Musky Base Note Fragrance Ingredient

ByThe Good Scents
Musky · Woody

7-Cyclohexadecen-1-one, (7E)

CAS 854373-70-9

Origin
synthetic
Note
Base
IFRA
Generally safe
Data as of: Apr 2026

What Is 7-Cyclohexadecen-1-one, (7E)?

7-Cyclohexadecen-1-one is a synthetic musk compound used in modern fragrances. It contributes to long-lasting, clean musk profiles. This ingredient matters because it provides an alternative to traditional animal-derived musks, offering sustainability benefits while maintaining performance.

Safety Profile

GENERALLY SAFE
Generally safeUse with awarenessProfessional use
✓ Safe in regulated products
⚠ Check local regulations for musk compound restrictions
CAS
854373-70-9
Formula
Mixture
MW
Variable
Odor Family
Musky · Woody
Layer 1 · Enthusiast

What Does 7-Cyclohexadecen-1-one, (7E) Smell Like?

7-Cyclohexadecen-1-one offers a clean, modern musk profile with subtle floral undertones. It evolves from a crisp opening to a warm, skin-like dry-down. The scent is reminiscent of freshly laundered linen with a sophisticated powdery finish, making it versatile for both masculine and feminine fragrances.

Scent Profile
Layer 2

Chemistry, Properties & Perfumer Guide

The Chemistry

7-Cyclohexadecen-1-one is a macrocyclic ketone, part of the synthetic musk family. It is synthesized through cyclization of long-chain fatty acids or via Diels-Alder reactions. Its structure allows for excellent stability and longevity in fragrance formulations.

Physical & Chemical Properties

Boiling PointN/A
DensityN/A

Perfumer Guide

Note Position
Base
Volatility
Low (hours to days)
Blending
Excellent
ApplicationTypical %RangeNotes
Fine Fragrance1-5%Up to 10%Provides long-lasting musk foundation

Classic Accords

Tip: Use as a base note to enhance longevity and add a clean musk character.

Alternatives & Comparisons

1
Galaxolide CAS 1222-05-5

A more traditional synthetic musk with a stronger laundry-like profile.

Layer 3

Safety, Regulatory & Sustainability

⚠ Regulatory Disclaimer

General reference only. Consult current IFRA Standards Library before formulating.

IFRA Status

No IFRA restrictions currently apply.

RIFM Assessment

RIFM safety assessment ongoing for synthetic musks.

Sustainability

Synthetic musks like 7-Cyclohexadecen-1-one offer a sustainable alternative to animal-derived musks. They are produced under controlled conditions, reducing environmental impact compared to traditional musk harvesting.

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References

    Data: PubChem (NIH), PubMed, RIFM, IFRA. Last reviewed: Apr 2026.

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    Ingredient Data Sheet

    CAS 854373-70-9

    Regulatory Status

    IFRA ListedYes — see IFRA Standards for category limits⚖️ IFRA 51
    Data Sources & Attribution
    Physical data: PubChem (NIH/NLM), U.S. EPA CompTox Dashboard, EPA OPERA models, RDKit. Odor & flavor: Arctander (Perfume & Flavor Chemicals), Fenaroli's Handbook of Flavor Ingredients, Leffingwell. Thresholds: van Gemert (Compilations of Odour Threshold Values). Regulatory: IFRA Standards 51st, FEMA GRAS. Trade names: Surburg (Common Fragrance & Flavor Materials). All data compiled and cross-referenced for perfumertools.com.

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