Anisaldehyde propyleneglycol acetal (CAS 6414-32-0) — Sweet Middle to base Note Fragrance Ingredient
Anisaldehyde propyleneglycol acetal
CAS 6414-32-0
What Is Anisaldehyde propyleneglycol acetal?
Anisaldehyde propyleneglycol acetal is a synthetic fragrance ingredient that adds a sweet, powdery, and slightly herbal character to perfumes. It is often found in floral and oriental fragrances. This ingredient matters because it provides long-lasting anisic (licorice-like) notes without the volatility of natural anise derivatives.
Safety Profile
GENERALLY SAFEWhat Does Anisaldehyde propyleneglycol acetal Smell Like?
Anisaldehyde propyleneglycol acetal opens with a soft, sweet anisic note reminiscent of licorice and star anise, but without the sharpness. As it evolves, it reveals a powdery, almost heliotropin-like character, blending seamlessly into floral compositions. The dry-down is smooth and slightly balsamic, with a subtle vanilla-like sweetness that lingers elegantly.
In Famous Fragrances
Fragrance associations may not reflect actual formulations.
Used to enhance the powdery, anisic facets of this classic floral-oriental, adding depth and longevity to the heliotrope note.
Contributes to the vanilla-anise accord, providing a smooth, sweet transition between top and base notes.
2D Molecular Structure
SMILES: COC1=CC=C(C=C1)C1OCC(C)O1
Chemistry, Properties & Perfumer Guide
The Chemistry
Anisaldehyde propyleneglycol acetal is a synthetic aromatic compound derived from anisaldehyde and propylene glycol. It belongs to the class of acetals, which are known for their stability and slow release of fragrance. The compound is typically synthesized through a condensation reaction between anisaldehyde and propylene glycol under acidic conditions.
Physical & Chemical Properties
| Boiling Point | Not available |
|---|---|
| Density | Not available |
Perfumer Guide
| Application | Typical % | Range | Notes |
|---|---|---|---|
| Fine Fragrance | 1-5% | Up to 10% | Adds sweet, powdery nuances |
| Soap | 0.5-2% | Up to 5% | Provides stability in alkaline conditions |
Classic Accords
Tip: Use in floral-oriental compositions to enhance powdery and sweet notes.
Alternatives & Comparisons
Safety, Regulatory & Sustainability
⚠ Regulatory Disclaimer
General reference only. Consult current IFRA Standards Library before formulating.
IFRA Status
No IFRA restrictions reported.
EU Allergen Declaration
Not listed as an EU allergen.
RIFM Assessment
No specific RIFM assessment found.
Sustainability
As a synthetic ingredient, anisaldehyde propyleneglycol acetal is produced in controlled environments, reducing the environmental impact compared to natural extraction. Its synthesis can be optimized for minimal waste and energy use.
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References
- PubChem: Anisaldehyde propyleneglycol acetal PubChem
Data: PubChem (NIH), PubMed, RIFM, IFRA. Last reviewed: Apr 2026.
Report a data errorIngredient Data Sheet
CAS 6414-32-0Physical Properties
| Molecular Weight | 194.23 g/mol🔬 PubChem |
| LogP (Octanol-Water) | 1.7🔬 PubChem |
| Boiling Point | 267 °C🔬 EPA CompTox |
| Vapor Pressure | 0.0006 mmHg @ 25°C📊 OPERA |
| Flash Point | 95.5 °C🔬 EPA CompTox |
| log Kp (skin permeability) | -2.678💻 Calculated |
| SMILES | CC1COC(O1)C2=CC=C(C=C2)OC🔬 PubChem |
Volatility & Performance
| Fragrance Note | Base💻 Calculated |
| Volatility Class | Very slow💻 Calculated |
| Persistence Score | 5 / 5💻 Calculated |
Odor & Flavor
| Primary Descriptors | floralherbalsweet• leffingwell |
| Functional Groups | etheraromatic💻 RDKit |
Physical data: PubChem (NIH/NLM), U.S. EPA CompTox Dashboard, EPA OPERA models, RDKit. Odor & flavor: Arctander (Perfume & Flavor Chemicals), Fenaroli's Handbook of Flavor Ingredients, Leffingwell. Thresholds: van Gemert (Compilations of Odour Threshold Values). Regulatory: IFRA Standards 51st, FEMA GRAS. Trade names: Surburg (Common Fragrance & Flavor Materials). All data compiled and cross-referenced for perfumertools.com.
Physicochemical Properties
DTXSID: DTXSID80863796
Physical Properties
| Molecular Weight | 194.23 g/mol🔬 EPA CompTox |
| Density | 1.09 g/cm^3📊 OPERA |
| Boiling Point | 275.166 °C📊 OPERA |
| Melting Point | 43.888 °C📊 OPERA |
| Flash Point | 104.975 °C📊 OPERA |
| Refractive Index | 1.503 Dimensionless📊 OPERA |
| Molar Volume | 178.981 cm^3/mol📊 OPERA |
Partition & Solubility
| LogP (Octanol-Water) | 2.242 Log10 unitless📊 OPERA |
| LogD (pH 5.5) | 2.242 Log10 unitless📊 OPERA |
| LogD (pH 7.4) | 2.242 Log10 unitless📊 OPERA |
| LogKoa (Octanol-Air) | 6.08 Log10 unitless📊 OPERA |
| Water Solubility | 0.011 mol/L📊 OPERA |
| Henry's Law Constant | 0 atm-m3/mole📊 OPERA |
Transport Properties
| Vapor Pressure | 0.002 mmHg📊 OPERA |
| Viscosity | 7.333 cP📊 OPERA |
| Surface Tension | 37.074 dyn/cm📊 OPERA |
| Thermal Conductivity | 132.463 mW/(m*K)📊 OPERA |
Molecular Descriptors
| Topological Polar Surface Area | 27.69 Ų💻 Computed |
| H-Bond Donors | 0 count💻 Computed |
| H-Bond Acceptors | 3 count💻 Computed |
| Rotatable Bonds | 2 count💻 Computed |
| Aromatic Rings | 1 count💻 Computed |
| Molar Refractivity | 52.876 cm^3/mol📊 OPERA |
| Polarizability | 20.962 Å^3📊 OPERA |
Data Sources:
🔬 EPA Experimental data from U.S. EPA CompTox Chemicals Dashboard & CTX APIs. 📊 OPERA Predicted using EPA's OPERA QSAR models. 💻 Computed Calculated from SMILES using RDKit.
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