endo-1,2,3,3-Tetramethylbicyclo[2.2.1]heptan-2-ol (CAS 28462-85-3) — Woody Middle to base Note Fragrance Ingredient

ByThe Good Scents
Woody · Balsamic

endo-1,2,3,3-Tetramethylbicyclo[2.2.1]heptan-2-ol

CAS 28462-85-3

Origin
synthetic
Note
Middle to base
IFRA
Generally safe
Data as of: Apr 2026

What Is endo-1,2,3,3-Tetramethylbicyclo[2.2.1]heptan-2-ol?

This synthetic ingredient is a specialized fragrance molecule used in modern perfumery to create unique woody-amber effects. It’s found in niche fragrances and some high-end personal care products. While not common, it’s valued for its ability to add depth and complexity to woody accords without being overpowering.

Safety Profile

GENERALLY SAFE
Generally safeUse with awarenessProfessional use
✓ No major safety concerns reported
⚠ Limited toxicological data available
CAS
28462-85-3
Formula
Mixture
MW
Variable
Odor Family
Woody · Balsamic
Layer 1 · Enthusiast

What Does endo-1,2,3,3-Tetramethylbicyclo[2.2.1]heptan-2-ol Smell Like?

A sophisticated woody-amber note with subtle camphoraceous undertones. Opens with a clean, slightly medicinal character that quickly evolves into a warm, dry woodiness reminiscent of aged cedar chests. The dry-down reveals a smooth, almost mineral-like quality with faint echoes of ambergris. Unlike many woody materials, it maintains excellent diffusion without becoming harsh or overpowering.

Scent Profile
Layer 2

2D Molecular Structure

(1R,2R,4S)-1,2,3,3-tetramethylbicyclo[2.2.1]heptan-2-ol

SMILES: CC1(C)[C@H]2CC[C@](C)(C2)[C@@]1(C)O

Chemistry, Properties & Perfumer Guide

The Chemistry

A bicyclic tertiary alcohol belonging to the camphor structural family. Synthesized through Diels-Alder reactions of pinene derivatives followed by selective hydrogenation and oxidation steps. The rigid bicyclic structure contributes to its stability and unique odor profile. The tetramethyl substitution pattern creates steric hindrance that affects both volatility and receptor binding.

Physical & Chemical Properties

Perfumer Guide

Note Position
Middle to base
Volatility
Moderate (2-6 hours)
Blending
Good
ApplicationTypical %RangeNotes
Fine Fragrance1-3%Up to 5%Woody accord enhancer
Home Care0.1-0.5%Up to 1%Long-lasting woody note

Classic Accords

Tip: Use sparingly to enhance woody bases without dominating the composition.

Alternatives & Comparisons

1
Norlimbanol CAS 70788-30-6

More powerful woody-amber material for stronger projection

2
Iso E Super CAS 54464-57-2

Softer woody alternative with better blending properties

Layer 3

Safety, Regulatory & Sustainability

⚠ Regulatory Disclaimer

General reference only. Consult current IFRA Standards Library before formulating.

IFRA Status

Not currently restricted by IFRA

RIFM Assessment

Not currently evaluated by RIFM

Sustainability

As a synthetic material, production avoids natural resource depletion. Manufacturing requires petrochemical feedstocks but at relatively low volumes due to high potency. No known environmental persistence or bioaccumulation concerns.

Explore endo-1,2,3,3-Tetramethylbicyclo[2.2.1]heptan-2-ol

Browse essential oils and aroma compounds.

Browse on iHerb →

Affiliate disclosure: we may earn a small commission at no extra cost to you.

References

    Data: PubChem (NIH), PubMed, RIFM, IFRA. Last reviewed: Apr 2026.

    Report a data error

    Ingredient Data Sheet

    CAS 28462-85-3

    Physical Properties

    Molecular Weight168.28 g/mol🔬 PubChem
    LogP (Octanol-Water)2.7🔬 PubChem
    Boiling Point214 °C🔬 EPA CompTox
    Vapor Pressure0.0631 mmHg @ 25°C📊 OPERA
    Flash Point83.5 °C🔬 EPA CompTox
    Involatility Index0.0052💻 Calculated
    log Kp (skin permeability)-1.81💻 Calculated
    SMILESCC1(C2CCC(C2)(C1(C)O)C)C🔬 PubChem

    Volatility & Performance

    Fragrance NoteHeart💻 Calculated
    Volatility ClassVery slow💻 Calculated
    Persistence Score2.1 / 5💻 Calculated

    Odor & Flavor

    Functional Groupsalcohol💻 RDKit
    Data Sources & Attribution
    Physical data: PubChem (NIH/NLM), U.S. EPA CompTox Dashboard, EPA OPERA models, RDKit. Odor & flavor: Arctander (Perfume & Flavor Chemicals), Fenaroli's Handbook of Flavor Ingredients, Leffingwell. Thresholds: van Gemert (Compilations of Odour Threshold Values). Regulatory: IFRA Standards 51st, FEMA GRAS. Trade names: Surburg (Common Fragrance & Flavor Materials). All data compiled and cross-referenced for perfumertools.com.

    Physicochemical Properties

    DTXSID: DTXSID8051964

    Physical Properties

    Molecular Weight 168.28 g/mol🔬 EPA CompTox
    Density 0.954 g/cm^3📊 OPERA
    Boiling Point 211.893 °C📊 OPERA
    Melting Point 86.136 °C📊 OPERA
    Flash Point 79.635 °C📊 OPERA
    Refractive Index 1.493 Dimensionless📊 OPERA
    Molar Volume 173.787 cm^3/mol📊 OPERA

    Partition & Solubility

    LogP (Octanol-Water) 2.985 Log10 unitless📊 OPERA
    LogD (pH 5.5) 2.985 Log10 unitless📊 OPERA
    LogD (pH 7.4) 2.985 Log10 unitless📊 OPERA
    LogKoa (Octanol-Air) 7.43 Log10 unitless📊 OPERA
    Water Solubility 0.007 mol/L📊 OPERA
    Henry's Law Constant 0 atm-m3/mole📊 OPERA

    Transport Properties

    Vapor Pressure 0.072 mmHg📊 OPERA
    Surface Tension 34.017 dyn/cm📊 OPERA
    Thermal Conductivity 121.408 mW/(m*K)📊 OPERA

    Molecular Descriptors

    Topological Polar Surface Area 20.23 Ų💻 Computed
    H-Bond Donors 1 count💻 Computed
    H-Bond Acceptors 1 count💻 Computed
    Rotatable Bonds 0 count💻 Computed
    Aromatic Rings 0 count💻 Computed
    Molar Refractivity 50.469 cm^3/mol📊 OPERA
    Polarizability 20.007 Å^3📊 OPERA

    Data Sources:

    🔬 EPA Experimental data from U.S. EPA CompTox Chemicals Dashboard & CTX APIs. 📊 OPERA Predicted using EPA's OPERA QSAR models. 💻 Computed Calculated from SMILES using RDKit.

    Similar Posts