Pyridine, 2-(2,4-dimethylcyclohexyl)- (CAS 885702-72-7) — Woody Middle to base Note Fragrance Ingredient
Pyridine, 2-(2,4-dimethylcyclohexyl)-
CAS 885702-72-7
What Is Pyridine, 2-(2,4-dimethylcyclohexyl)-?
Pyridine, 2-(2,4-dimethylcyclohexyl)- is a synthetic aromatic compound used in niche fragrances. It adds a sharp, slightly medicinal character to compositions. This ingredient matters because it provides unique tonalities that can’t be achieved with natural materials alone, allowing perfumers to create avant-garde accords.
Safety Profile
USE WITH AWARENESSWhat Does Pyridine, 2-(2,4-dimethylcyclohexyl)- Smell Like?
A piercing aromatic burst with metallic undertones evolves into a dry, woody-herbaceous heart. The dry-down reveals a persistent leathery nuance reminiscent of aged library books and antique brass fittings. Its tenacious character makes it useful for creating olfactory ‘anchors’ in modern chypre compositions.
In Famous Fragrances
Fragrance associations may not reflect actual formulations.
Used as the sole aroma chemical to demonstrate how this synthetic pyridine derivative can create a full fragrance experience with its evolving woody-metallic character.
2D Molecular Structure
SMILES: CC1CCC(C(C)C1)C1=CC=CC=N1
Chemistry, Properties & Perfumer Guide
The Chemistry
This substituted pyridine belongs to the heterocyclic aromatic compounds class. The dimethylcyclohexyl group adds steric hindrance that modifies both volatility and odor characteristics compared to simpler pyridines. Synthesis typically involves catalytic hydrogenation of corresponding pyridine precursors.
Physical & Chemical Properties
| Molecular Weight | Not publicly available |
|---|---|
| Boiling Point | Not publicly available |
Perfumer Guide
| Application | Typical % | Range | Notes |
|---|---|---|---|
| Fine Fragrance | 0.1-0.5% | Up to 1% | Used as accent note |
| Functional Fragrance | 0.01-0.1% | Up to 0.2% | Masking agent |
Classic Accords
Tip: Use sparingly in woody bases to add cutting edge to conventional materials.
Alternatives & Comparisons
When a more popcorn-like nuance is desired while maintaining pyridine characteristics.
Safety, Regulatory & Sustainability
⚠ Regulatory Disclaimer
General reference only. Consult current IFRA Standards Library before formulating.
IFRA Status
Not currently restricted by IFRA standards.
GHS Classification
RIFM Assessment
No published RIFM assessment available.
Sustainability
As a synthetic material, production involves petrochemical feedstocks. The environmental impact depends on manufacturing processes and energy sources. Being used in trace amounts minimizes ecological footprint per finished product.
Explore Pyridine, 2-(2,4-dimethylcyclohexyl)-
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References
- PubChem Compound Summary for Pyridine derivatives PubChem
Data: PubChem (NIH), PubMed, RIFM, IFRA. Last reviewed: Apr 2026.
Report a data errorIngredient Data Sheet
CAS 885702-72-7Physical Properties
| Molecular Weight | 189.3 g/mol🔬 PubChem |
| LogP (Octanol-Water) | 3.7🔬 PubChem |
| Boiling Point | 259 °C🔬 EPA CompTox |
| Vapor Pressure | 0.012 mmHg @ 25°C📊 OPERA |
| Flash Point | 133 °C🔬 EPA CompTox |
| Involatility Index | 0.0009💻 Calculated |
| log Kp (skin permeability) | -1.228💻 Calculated |
| SMILES | CC1CCC(C(C1)C)C2=CC=CC=N2🔬 PubChem |
Volatility & Performance
| Fragrance Note | Heart💻 Calculated |
| Volatility Class | Very slow💻 Calculated |
| Persistence Score | 3.9 / 5💻 Calculated |
Odor & Flavor
| Primary Descriptors | spicywoody• leffingwell |
| Functional Groups | aromatic💻 RDKit |
Physical data: PubChem (NIH/NLM), U.S. EPA CompTox Dashboard, EPA OPERA models, RDKit. Odor & flavor: Arctander (Perfume & Flavor Chemicals), Fenaroli's Handbook of Flavor Ingredients, Leffingwell. Thresholds: van Gemert (Compilations of Odour Threshold Values). Regulatory: IFRA Standards 51st, FEMA GRAS. Trade names: Surburg (Common Fragrance & Flavor Materials). All data compiled and cross-referenced for perfumertools.com.
Physicochemical Properties
DTXSID: DTXSID10889227
Physical Properties
| Molecular Weight | 189.302 g/mol🔬 EPA CompTox |
| Density | 0.965 g/cm^3📊 OPERA |
| Boiling Point | 272.413 °C📊 OPERA |
| Melting Point | 41.794 °C📊 OPERA |
| Flash Point | 126.214 °C📊 OPERA |
| Refractive Index | 1.497 Dimensionless📊 OPERA |
| Molar Volume | 203.845 cm^3/mol📊 OPERA |
Partition & Solubility
| LogP (Octanol-Water) | 4.058 Log10 unitless📊 OPERA |
| LogD (pH 5.5) | 3.559 Log10 unitless📊 OPERA |
| LogD (pH 7.4) | 4.045 Log10 unitless📊 OPERA |
| LogKoa (Octanol-Air) | 6.63 Log10 unitless📊 OPERA |
| Water Solubility | 0.002 mol/L📊 OPERA |
| Henry's Law Constant | 0.001 atm-m3/mole📊 OPERA |
Transport Properties
| Vapor Pressure | 0.007 mmHg📊 OPERA |
| Viscosity | 14.046 cP📊 OPERA |
| Surface Tension | 33.34 dyn/cm📊 OPERA |
| Thermal Conductivity | 130.624 mW/(m*K)📊 OPERA |
Molecular Descriptors
| Topological Polar Surface Area | 12.89 Ų💻 Computed |
| H-Bond Donors | 0 count💻 Computed |
| H-Bond Acceptors | 1 count💻 Computed |
| Rotatable Bonds | 1 count💻 Computed |
| Aromatic Rings | 1 count💻 Computed |
| Molar Refractivity | 59.622 cm^3/mol📊 OPERA |
| Polarizability | 23.636 Å^3📊 OPERA |
Data Sources:
🔬 EPA Experimental data from U.S. EPA CompTox Chemicals Dashboard & CTX APIs. 📊 OPERA Predicted using EPA's OPERA QSAR models. 💻 Computed Calculated from SMILES using RDKit.
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